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In settings where resistance and rampant misinformation against vaccines exist, the prospect of ending infectious diseases remains a challenge. Can delivery of information regarding the benefits of vaccination through personal home visits by local ambassadors increase vaccine uptake? We conduct a door-to-door randomised information campaign targeted towards COVID-19 unvaccinated individuals in rural Indonesia. We recruited ambassadors—health cadres, nominated influential individuals, and laypersons—from local villages tasked to deliver evidence-based information about COVID-19 vaccines and promote vaccination through one-on-one meetings, using an interpersonal behavioral change communication approach. To investigate which type of ambassador is the most effective, we carry out a cluster randomised experiment that varies the type of ambassador that delivers the information at the village level. We examine the impacts of our intervention on the following primary outcomes: vaccination take-up, vaccination registration, and vaccination intention.