Antimicrobial resistance (AMR) is a dominant and growing global health threat that led to 1.27 million deaths in 2019. Given the widespread use of antimicrobials in healthcare, agriculture, and industrial applications and a range of factors affecting AMR, including climate variability and demographic trends, an economy-wide approach is essential to assess its economic consequences. This study models the economic consequences of AMR under eight scenarios accounting for the changes in AMR-related disease incidence, livestock productivity, and financial risks. The results illustrate the global economic burden and adjustments of worsening AMR, and emphasize a one-health approach to managing AMR.